Anthropic says it retrained Claude Fable 5's biology safety classifiers so far fewer benign queries fall back to a weaker model. Internal tests showed about an 85% drop in biology-related fallbacks, which should help everyday health questions and some clinical support. Dual-use work such as virology, toxicology and molecular design still routes away from Fable, and professional drug-development help remains blocked pending trusted-access paths. Caveat: Anthropic reports the gain itself; independent checks on remaining false positives and jailbreak resistance are not public yet.