A NEJM AI study across RWJBarnabas Health found Epic’s Deterioration Index, paired with automatic rapid-response alerts, cut high-risk inpatient mortality from 23.1% to 18.6% — about an 18% drop in risk-adjusted odds — while raising response-team activations. Leaders stress earlier critical-care eyes, not autonomous treatment. Follow-on work targets patients whose risk scores are rising fast. It matters because an EHR-native tool already in wide use may translate beyond one health system. Caveat: single-network results still need broader replication before national standard-of-care claims.